In its hallowed journey of evolving as a torchbearer of academic enlightenment, beginning with its founder, Rev. Dr. Alexander Duff, the college has been led by distinguished visionaries. They have been instrumental in setting up exemplary standards of excellence, imbibing a profound sense of dedication towards the holistic upliftment of the students and a zeal for serving the nation. The college is privileged to have an illustrious list of Principals as mentioned below.

General Assembly's Institution (1830-1908)
Rev. Dr. Alexander Duff	1830-1834
Rev. William Sinclair Mackay & Rev. David Ewart	1834-1839
Rev. Dr. Alexander Duff	1840-1843
Rev. Dr. James Ogilvie	1845-1871
Rev. William Hastie	1878-1884
Rev. William Smith	1884-1889
Rev. John Morrison	1889-1904
Rev. Andrew Blair Wann	1904-1908

Free Chruch Institution (1843 - 1863)
Rev. Dr. Alexander Duff	1843-1863

Duff College (1863-1908)
Rev. W.C. Fyfe	1863-1880
Rev. James Robertson	1881-1883
Rev. John Hector	1883-1902

Scottish Churches College (1908-1929)
Rev. Andrew Blair Wann	1908-1909
Rev. John Lamb	1909-1910
Rev. Alexander Tomory	1910
Rev. John Lamb	1910-1911
Rev. Dr. James Watt	1911-1928
Rev. Dr. William Spence Urquhart	1928-1929

Scottish Church College (1929 Onwards)
Rev. William Spence Urquhart	1929-1937
Rev. Allen Cameron	1937-1944
Rev. John Kellas	1944-1954
Prof. Dr. Harold John Taylor	1954-1960
Prof. Dr. Nirmal Kumar Mundle	1960-1970
Prof. Jyotsna Kumar Pyne	1970
Prof. Bivakar Das	1970-1971
Prof. Santi Kumar Mitra	1971-1973
Prof. Keshub Dutta Bhatt	1973-1975
Prof. Sushil Kumar Mukherjee	1975-1976
Prof Anil Kumar Sen	1976-1978
Prof Amiya Kumar Kisku	1978-1981
Prof. Aparesh Bhattacharyya	1981-1983
Prof. Kalyan Chunder Dutt	1983-1995
Prof. Dr. Kalyan Kumar Mandi	1996-2002
Prof. Dr. John Abraham	2002-2013
Prof. Dr. Amit Abraham	2015-2016
Dr. Arpita Mukerji (Teacher In-Charge)	2016-2018
Dr. Arpita Mukerji (Principal)	2018-2021
Dr. Madhumanjari Mandal	2021-